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Article

Transmembrane domain length affects charge-mediated retention and degradation of proteins within the endoplasmic reticulum.

The Journal of biological chemistry - 5 Mar 1993

Lankford S P, Cosson P, Bonifacino J S, Klausner R D

Abstract excerpt

Previous studies have shown that the presence of potentially charged amino acid residues within the transmembrane domains of type I integral membrane proteins can result in protein retention and, in some cases, degradation within the endoplasmic reticulum (ER). An apparent exception to this observation is the CD3-epsilon chain of the T-cell antigen receptor complex, which is relatively stable in spite of having a...

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PMID: 8444858

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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