Transmembrane domain length affects charge-mediated retention and degradation of proteins within the endoplasmic reticulum.

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Article

Transmembrane domain length affects charge-mediated retention and degradation of proteins within the endoplasmic reticulum.

The Journal of biological chemistry - 5 Mar 1993

Lankford S P, Cosson P, Bonifacino J S, Klausner R D

Abstract excerpt

Previous studies have shown that the presence of potentially charged amino acid residues within the transmembrane domains of type I integral membrane proteins can result in protein retention and, in some cases, degradation within the endoplasmic reticulum (ER). An apparent exception to this obser...

Topics

Amino Acid Sequence
Aspartic Acid
CD3 Complex
Cell Line
Electrochemistry
Endoplasmic Reticulum
Intracellular Membranes
Membrane Proteins
Molecular Sequence Data
Mutation
Receptors, Interleukin-2

Source

Open in PubMed

Identifiers

PMID: 8444858

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8444858-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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