Article
Identification of a consensus motif for retention of transmembrane proteins in the endoplasmic reticulum.
The EMBO journal - 1 Oct 1990
Jackson M R, Nilsson T, Peterson P A
Abstract excerpt
Several families of transmembrane endoplasmic reticulum (ER) proteins contain retention motifs in their cytoplasmically exposed tails. Mutational analyses demonstrated that two lysines positioned three and four or five residues from the C-terminus represent the retention motif. The introduction o...
Topics
- Amino Acid Sequence
- Animals
- Antigens, CD
- Antigens, Differentiation, T-Lymphocyte
- Base Sequence
- CD8 Antigens
- DNA, Recombinant
- Endoplasmic Reticulum
- Flow Cytometry
- Fluorescent Antibody Technique
- HeLa Cells
- Humans
- Lysine
- Membrane Proteins
- Molecular Sequence Data
- Mutation
- Oligonucleotide Probes
- Sequence Homology, Nucleic Acid