Alteration of N-terminal residues of mature human lysozyme affects its secretion in yeast and translocation into canine microsomal vesicles.

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Article

Alteration of N-terminal residues of mature human lysozyme affects its secretion in yeast and translocation into canine microsomal vesicles.

The Journal of biological chemistry - 25 Oct 1991

Kohara A, Yamamoto Y, Kikuchi M

Abstract excerpt

Signal sequences play a central role in the initial membrane translocation of secretory proteins. Their functions depend on factors such as hydrophobicity and conformation of the signal sequences themselves. However, some characteristics of mature proteins, especially those of the N-terminal region, might also affect the function of the signal sequences. To examine this possibility, several mutants of human...

Topics

Amino Acid Sequence
Animals
Base Sequence
Blotting, Western
Cell Membrane
Dogs
Glycosylation
Humans
Microsomes
Molecular Sequence Data
Muramidase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Protein Biosynthesis

RNA, Fungal

RNA, Messenger

Saccharomyces cerevisiae

Transcription, Genetic

Translocation, Genetic

Source

Open in PubMed

Identifiers

PMID: 1939091

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1939091-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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