Article
Down-regulation of cell surface receptors is modulated by polar residues within the transmembrane domain.
Molecular biology of the cell - 1 Aug 2000
Zaliauskiene L, Kang S, Brouillette C G, Lebowitz J, Arani R B, Collawn J F
Abstract excerpt
How recycling receptors are segregated from down-regulated receptors in the endosome is unknown. In previous studies, we demonstrated that substitutions in the transferrin receptor (TR) transmembrane domain (TM) convert the protein from an efficiently recycling receptor to one that is rapidly down regulated. In this study, we demonstrate that the "signal" within the TM necessary and sufficient for down-regulation...
Topics
- Amino Acid Sequence
- Animals
- Antigens, Differentiation, B-Lymphocyte
- Chick Embryo
- Cross-Linking Reagents
- Down-Regulation
- Endocytosis
- Fibroblasts
- Half-Life
- Histocompatibility Antigens Class II
- Lysosomes
- Models, Molecular
- Molecular Sequence Data