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Article

Function of the hydrophobic transmembrane portion of Thy-1 antigen.

Microbiology and immunology - 1 Jan 1990

Tate G

Abstract excerpt

Thy-1 antigen is anchored in the cell membrane by glycophosphatidyl inositol linkages instead of hydrophobic protein domains. The hydrophobic portion of Thy-1 antigen is cleaved by putative "transamidase." Mutated genes were constructed by using site-directed mutagenesis. One mutant gene codes Thy-1 antigen lacking carboxy terminal amino acids from 112Cys to 143Leu including cell membrane binding amino acid...

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PMID: 1975422
DOI: 10.1111/j.1348-0421.1990.tb01031.x

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