Article
Transport and secretion of truncated T cell receptor beta-chain occurs in the absence of association with CD3.
The Journal of biological chemistry - 5 Jun 1990
Gascoigne N R
Abstract excerpt
The T cell receptor (TCR) beta-chain is produced in the endoplasmic reticulum where it associates with the TCR alpha-chain and the members of the CD3 complex to form the complete receptor. When the other chains of the complex are not available, the beta-chain is rapidly degraded within the endopl...
Topics
- Acetylglucosaminidase
- Amino Acid Sequence
- Animals
- Antigens, CD
- Antigens, Differentiation, T-Lymphocyte
- B-Lymphocytes
- Base Sequence
- Biological Transport
- CD3 Complex
- Cloning, Molecular
- Endoplasmic Reticulum
- Gene Expression
- Glycosylation
- Golgi Apparatus
- Immunosorbent Techniques
- Macromolecular Substances
- Mannosyl-Glycoprotein Endo-beta-N-Acetylglucosaminidase
- Mice