Article
Role of potentially charged transmembrane residues in targeting proteins for retention and degradation within the endoplasmic reticulum.
The EMBO journal - 1 Oct 1991
Bonifacino J S, Cosson P, Shah N, Klausner R D
Abstract excerpt
The selective breakdown of newly synthesized proteins retained within the endoplasmic reticulum (ER) is probably mediated by the specific recognition of structural features of protein substrates by components of a degradative system. Within the alpha chain of the multisubunit T-cell antigen recep...
Topics
- Amino Acid Sequence
- Biological Transport, Active
- Cell Line
- Electrochemistry
- Electrophoresis, Polyacrylamide Gel
- Endoplasmic Reticulum
- Hydrolysis
- Membrane Proteins
- Microscopy, Fluorescence
- Molecular Sequence Data
- Mutation
- Phenotype
- Protein Conformation
- Receptors, Antigen, T-Cell
- Receptors, Interleukin-2
- Recombinant Fusion Proteins