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Somatic mutations and human breast cancer. A status report.

Cancer - 15 Mar 1992

Callahan R, Cropp C S, Merlo G R, Liscia D S, Cappa A P, Lidereau R

Abstract excerpt

A systematic study of primary human breast tumor DNA demonstrated that three proto-oncogenes or regions of the genome (c-myc, int-2, and c-erbB2) are frequently amplified and that there is loss of heterozygosity (LOH) on chromosomes 1p(37%), 1q(20%), 3p(30%), 7(41%), 11p(20%), 13q(30%), 17p(49%), 17q(29%), and 18q(34%). Specific subsets of tumors can be defined based on the particular collection of mutations they...

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PMID: 1540899
DOI: 10.1002/1097-0142(19920315)69:6+<1582::aid-cncr2820691313>3.0.co;2-y

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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