Article
Growth suppression of Friend virus-transformed erythroleukemia cells by p53 protein is accompanied by hemoglobin production and is sensitive to erythropoietin.
Molecular and cellular biology - 1 Mar 1993
Johnson P, Chung S, Benchimol S
Abstract excerpt
The murine allele temperature-sensitive (ts) p53Val-135 encodes a ts p53 protein that behaves as a mutant polypeptide at 37 degrees C and as a wild-type polypeptide at 32 degrees C. This ts allele was introduced into the p53 nonproducer Friend erythroleukemia cell line DP16-1. The DP16-1 cell lin...
Topics
- Animals
- Cell Cycle
- Cell Differentiation
- Cell Division
- Cell Line, Transformed
- Cell Transformation, Viral
- Erythropoietin
- Friend murine leukemia virus
- Hemoglobins
- Leukemia, Erythroblastic, Acute
- Mice
- Mice, Inbred DBA
- Mutation
- Recombinant Proteins
- Spleen
- Spleen Focus-Forming Viruses
- Tumor Suppressor Protein p53
- Viral Envelope Proteins