Article
Alteration of p53 conformation and induction of apoptosis in a murine erythroleukemia cell line by dimethylsulfoxide.
Leukemia research - 1 Aug 1994
Ryan J J, Clarke M F
Abstract excerpt
Programmed cell death, or apoptosis, may play an important role in the regulation of hematopoiesis. The tumor suppressor protein p53 has been identified as a key regulator of apoptosis in both normal and malignant hematopoietic cells. Modulation of p53 function is of interest, therefore, both in understanding the control of apoptosis and as a potential therapeutic intervention. In this study we describe the...
Topics
- Animals
- Apoptosis
- Cell Nucleus
- Dimethyl Sulfoxide
- Immunohistochemistry
- Leukemia, Erythroblastic, Acute
- Mice
- Mutation
- Precipitin Tests
- Protein Conformation
- Transfection