Article
A mouse erythroleukemia cell line possessing friend spleen focus-forming virus gp55 transgene and temperature-sensitive mutant p53 gene.
Japanese journal of cancer research : Gann - 1 Mar 1995
Xu X, Yamamura Y, Tsukada T, Yoshida M A, Senda H, Nagayoshi M, Ikeuchi T, Ikawa Y
Abstract excerpt
Two different erythroleukemia cell lines have been established from the splenic lesions of transgenic mice possessing the Friend spleen focus-forming virus (F-SFFV) gp55 gene. One showed a near-diploid karyotype and a temperature-sensitive (ts) p53 mutation, and the other, a hyper-triploid karyotype with double p53 mutations found by single-strand conformation polymorphism (SSCP) analysis. The cell lines both...
Topics
- Animals
- Base Sequence
- Genes, p53
- Karyotyping
- Leukemia, Erythroblastic, Acute
- Mice
- Mice, Inbred C57BL
- Mice, Transgenic
- Molecular Sequence Data
- Mutation
- Point Mutation