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Article

Fusion of the erythropoietin receptor and the Friend spleen focus-forming virus gp55 glycoprotein transforms a factor-dependent hematopoietic cell line.

Molecular and cellular biology - 1 Feb 1993

Showers M O, DeMartino J C, Saito Y, D'Andrea A D

Abstract excerpt

The Friend spleen focus-forming virus (SFFV) gp55 glycoprotein binds to the erythropoietin receptor (EPO-R), causing constitutive receptor signaling and the first stage of Friend erythroleukemia. We have used three independent strategies to further define this transforming molecular interaction. First, using a retroviral selection strategy, we have isolated the cDNAs encoding three fusion polypeptides containing...

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Identifiers

PMID: 8423798
DOI: 10.1128/mcb.13.2.739-748.1993
PMCID: PMC358956

Genes

EPO

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Fusion of the erythropoietin receptor and the Friend spleen focus-forming virus gp55 glycoprotein transforms a factor-dependent hematopoietic cell line.PMID 8423798Read ↗

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Selectable retrovirus vectors encoding Friend virus gp55 or erythropoietin induce polycythemia with different phenotypic expression and disease progression.Semantic proximity Read ↗

Cell surface site for mitogenic interaction of erythropoietin receptors with the membrane glycoprotein encoded by Friend erythroleukemia virus.Semantic proximity Read ↗

The envelope glycoprotein of friend spleen focus-forming virus covalently interacts with and constitutively activates a truncated form of the receptor tyrosine kinase Stk.Semantic proximity Read ↗

A Friend virus mutant that overcomes Fv-2rr host resistance encodes a small glycoprotein that dimerizes, is processed to cell surfaces, and specifically activates erythropoietin receptors.Semantic proximity Read ↗

The erythropoietin receptor transmembrane domain mediates complex formation with viral anemic and polycythemic gp55 proteins.Semantic proximity Read ↗

Deletions in one domain of the Friend virus-encoded membrane glycoprotein overcome host range restrictions for erythroleukemia.Semantic proximity Read ↗

A Friend virus mutant encodes a small glycoprotein that causes erythroleukemia.Semantic proximity Read ↗

Pathogenesis of Friend leukemia virus.Semantic proximity Read ↗

Role of N-terminal sequences of the tyrosine kinase sf-Stk in transformation of rodent fibroblasts by variants of Friend spleen focus-forming virus.Semantic proximity Read ↗

The cytoplasmic region of the erythropoietin receptor contains nonoverlapping positive and negative growth-regulatory domains.Semantic proximity Read ↗

Mutation in murine erythropoietin receptor induces erythropoietin-independent erythroid proliferation in vitro, polycythemia in vivo.Semantic proximity Read ↗

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