Deletions in one domain of the Friend virus-encoded membrane glycoprotein overcome host range restrictions for erythroleukemia.

doi:10.1128/JVI.69.2.856-863.1995

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Article

Deletions in one domain of the Friend virus-encoded membrane glycoprotein overcome host range restrictions for erythroleukemia.

Journal of virology - 1 Feb 1995

Hoatlin M E, Ferro F E, Geib R W, Fox M T, Kozak S L, Kabat D

Abstract excerpt

Although the Friend virus-encoded membrane glycoprotein (gp55) activates erythropoietin receptors (EpoR) to cause erythroblastosis only in certain inbred strains of mice but not in other species, mutant viruses can overcome aspects of mouse resistance. Thus, mice homozygous for the resistance all...

Topics

Animals
Gene Products, env
Leukemia, Erythroblastic, Acute
Mice
Mice, Inbred DBA
Mutation
Receptors, Erythropoietin
Spleen Focus-Forming Viruses
Viral Envelope Proteins

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