Article
Escape from redox regulation enhances the transforming activity of Fos.
Oncogene - 1 Mar 1993
Okuno H, Akahori A, Sato H, Xanthoudakis S, Curran T, Iba H
Abstract excerpt
Fos and Jun form dimeric complexes that bind to DNA sequences containing activator protein 1 (AP-1) sites and regulate gene expression. The in vitro DNA-binding activity of these proteins is sensitive to reduction-oxidation (redox). Reduction of a single conserved cysteine residue, located in the DNA-binding domain, either by reducing agents or by a nuclear redox factor (Ref-1), is required for AP-1 DNA-binding...
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