Escape from redox regulation enhances the transforming activity of Fos.

Article

Escape from redox regulation enhances the transforming activity of Fos.

Oncogene - 1 Mar 1993

Okuno H, Akahori A, Sato H, Xanthoudakis S, Curran T, Iba H

Abstract excerpt

Fos and Jun form dimeric complexes that bind to DNA sequences containing activator protein 1 (AP-1) sites and regulate gene expression. The in vitro DNA-binding activity of these proteins is sensitive to reduction-oxidation (redox). Reduction of a single conserved cysteine residue, located in the...

Topics

Animals
Cell Transformation, Neoplastic
Chick Embryo
DNA
Mutation
Oxidation-Reduction
Proto-Oncogene Proteins c-fos
Proto-Oncogene Proteins c-jun
Structure-Activity Relationship

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.