Article
Trans-dominant negative mutants of Fos and Jun.
Proceedings of the National Academy of Sciences of the United States of America - 1 May 1990
Ransone L J, Visvader J, Wamsley P, Verma I M
Abstract excerpt
Jun and Fos nuclear oncoproteins form a complex that regulates transcription from promoters containing activator protein AP-1 binding sites. The leucine-zipper and basic-region domains of both Fos and Jun are necessary for formation of the heterodimer that binds to DNA. Reciprocal mutations in the basic region of Fos or Jun can influence the binding of the heterodimer to DNA, implying a symmetrical binding site....
Topics
- Amino Acid Sequence
- Animals
- Cell Line
- Cloning, Molecular
- DNA-Binding Proteins
- Gene Expression
- Genes, Dominant
- Humans
- Mice
- Molecular Sequence Data
- Mutation
- Protein-Tyrosine Kinases