Article
Coactivator MBF1 preserves the redox-dependent AP-1 activity during oxidative stress in Drosophila.
The EMBO journal - 1 Sept 2004
Jindra Marek, Gaziova Ivana, Uhlirova Mirka, Okabe Masataka, Hiromi Yasushi, Hirose Susumu
Abstract excerpt
Basic leucine zipper proteins Jun and Fos form the dimeric transcription factor AP-1, essential for cell differentiation and immune and antioxidant defenses. AP-1 activity is controlled, in part, by the redox state of critical cysteine residues within the basic regions of Jun and Fos. Mutation of these cysteines contributes to oncogenic potential of Jun and Fos. How cells maintain the redox-dependent AP-1...
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