Article
Transcriptional activation and repression by Fos are independent functions: the C terminus represses immediate-early gene expression via CArG elements.
Molecular and cellular biology - 1 Aug 1990
Gius D, Cao X M, Rauscher F J, Cohen D R, Curran T, Sukhatme V P
Abstract excerpt
The Fos-Jun complex has been shown to activate transcription through the regulatory element known as the AP-1 binding site. We show that Fos down regulates several immediate-early genes (c-fos, Egr-1, and Egr-2) after mitogenic stimulation. Specifically, we demonstrate that the target for this repression is a sequence of the form CC(A/T)6GG, also known as a CArG box. Whereas Fos bound to the AP-1 site through a...
Topics
- Animals
- Base Sequence
- Cells, Cultured
- Chromosome Deletion
- DNA-Binding Proteins
- Gene Expression Regulation
- Mice
- Molecular Sequence Data
- Mutation
- Oligonucleotide Probes
- Plasmids