Accumulated helix-destabilizing mutations in the leucine zipper of c-Fos leads to attenuation and temperature sensitivity of function.

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Article

Accumulated helix-destabilizing mutations in the leucine zipper of c-Fos leads to attenuation and temperature sensitivity of function.

Oncogene - 1 Jul 1993

Nicklin M J, Zechner D, Kislyakova T

Abstract excerpt

Fos protein heterodimerizes through one surface of an alpha-helical domain called the leucine zipper. We have investigated the effect of destabilizing this domain by multiply substituting small residues of its non-interacting surface with glycine. Ternary complex formation between mutated Fos, Ju...

Topics

Animals
Base Sequence
Cell Division
Cell Line
Gene Expression
Genes, fos
Leucine Zippers
Molecular Sequence Data
Mutation
Protein Structure, Secondary
Proto-Oncogene Proteins c-fos
Proto-Oncogene Proteins c-jun
Rats
Structure-Activity Relationship
Temperature

Source

Open in PubMed

Identifiers

PMID: 8510920

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8510920-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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