Gene transplantation: combined antisense inhibition and gene replacement strategies.

Article

Gene transplantation: combined antisense inhibition and gene replacement strategies.

Leukemia - 1 Apr 1994

Robinson-Benion C, Li Y X, Holt J T

Abstract excerpt

Optimal gene replacement protocols would include both inhibition of the endogenous gene and overexpression of the preferred (or mutant) gene. We have developed a novel gene transfer method to test whether antisense-resistant genes (designed by deletion of antisense RNA target sequences) can repla...

Topics

Blood Physiological Phenomena
DNA
Gene Transfer Techniques
Genes, fos
Genetic Therapy
Humans
Mutation
Proto-Oncogene Proteins c-fos
RNA, Antisense

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