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Article

Cysteine 64 of Ref-1 is not essential for redox regulation of AP-1 DNA binding.

Molecular and cellular biology - 1 Jun 2003

Ordway Jared M, Eberhart Derek, Curran Tom

Abstract excerpt

Ref-1 participates in DNA repair as well as in redox regulation of transcription factor function. The redox function of Ref-1 involves reduction of oxidized cysteine residues within the DNA binding domains of several transcription factors, including Fos and Jun. Reduction of these residues is required for DNA binding, providing a redox-dependent mechanism for regulation of target gene expression. Previous in...

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Identifiers

PMID: 12773568
DOI: 10.1128/MCB.23.12.4257-4266.2003
PMCID: PMC156143

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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