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Article

Frequent loss of heterozygosity on chromosome 14 occurs in advanced colorectal carcinomas.

Oncogene - 1 Mar 1993

Young J, Leggett B, Ward M, Thomas L, Buttenshaw R, Searle J, Chenevix-Trench G

Abstract excerpt

The current model for colorectal tumorigenesis defines four specific mutations (activation of a ras proto-oncogene and inactivation of the APC, p53 and DCC tumor-suppressor genes) that accumulate in a colonic epithelial cell as it progresses towards a carcinoma. However, further mutations must be needed for progression to malignancy because advanced adenomas have been observed with all four of these mutations....

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Source

Identifiers

PMID: 8437850

Genes

APC
DCC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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