Frequent loss of heterozygosity on chromosome 14 occurs in advanced colorectal carcinomas.

Article

Frequent loss of heterozygosity on chromosome 14 occurs in advanced colorectal carcinomas.

Oncogene - 1 Mar 1993

Young J, Leggett B, Ward M, Thomas L, Buttenshaw R, Searle J, Chenevix-Trench G

Abstract excerpt

The current model for colorectal tumorigenesis defines four specific mutations (activation of a ras proto-oncogene and inactivation of the APC, p53 and DCC tumor-suppressor genes) that accumulate in a colonic epithelial cell as it progresses towards a carcinoma. However, further mutations must be...

Topics

Adenocarcinoma
Adenoma
Carcinoma
Chromosome Deletion
Chromosomes, Human, Pair 14
Colorectal Neoplasms
Heterozygote
Humans
Mutation
Proto-Oncogene Mas

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