Loss of heterozygosity on the long arm of chromosome 11 in colorectal tumours.

doi:10.1038/bjc.1994.315

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Article

Loss of heterozygosity on the long arm of chromosome 11 in colorectal tumours.

British journal of cancer - 1 Sept 1994

Gustafson C E, Young J, Leggett B, Searle J, Chenevix-Trench G

Abstract excerpt

We have examined a series of human colorectal adenomas, carcinomas and cell lines derived from human colorectal cancer for loss of heterozygosity (LOH) on chromosome 11q22-23 by polymerase chain reaction (PCR) amplification of a microsatellite polymorphism of the dopamine D2 receptor (DRD2) locus...

Topics

Adenoma
Aged
Alleles
Chromosomes, Human, Pair 11
Colorectal Neoplasms
Female
Gene Deletion
Genetic Variation
Heterozygote
Humans
Male
Mutation
Polymerase Chain Reaction
Receptors, Dopamine D2
Tumor Cells, Cultured

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