Article
Recurrent deletions at 6q in early age of onset non-HNPCC- and non-FAP-associated intestinal carcinomas. Evidence for a novel cancer susceptibility locus at 6q14-q22.
Genes, chromosomes & cancer - 1 Feb 2008
Bläker Hendrik, Mechtersheimer Gunhild, Sutter Christian, Hertkorn Christian, Kern Michael A, Rieker Ralf J, Penzel Roland, Schirmacher Peter, Kloor Matthias
Abstract excerpt
Hereditary intestinal cancers mainly occur in the framework of the familial adenomatous polyposis (FAP) and hereditary nonpolyposis colorectal cancer (HNPCC) syndromes. However, in about 50% of young patients with intestinal cancer clinically suspicious of an inherited cancer predisposition, no underlying molecular alteration can be identified. To determine the genetic profile of early onset intestinal cancer in...
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