The E1B 19-kilodalton protein is not essential for transformation of rodent cells in vitro by adenovirus type 5.

doi:10.1128/JVI.67.3.1600-1611.1993

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Article

The E1B 19-kilodalton protein is not essential for transformation of rodent cells in vitro by adenovirus type 5.

Journal of virology - 1 Mar 1993

Telling G C, Williams J

Abstract excerpt

The newly constructed adenovirus type 5 mutant in1 carries a single AT base pair insertion immediately after nucleotide position 1715 in the E1B gene sequence which destroys the proximal AUG normally present in E1B messages and prevents production of intact E1B 19-kDa protein in infected cells. W...

Topics

Adenoviridae
Adenovirus E1B Proteins
Animals
Base Sequence
Cell Death
Cell Survival
Cell Transformation, Viral
Cells, Cultured
DNA
DNA, Viral
Genetic Variation
Mice
Molecular Sequence Data
Mutation
Open Reading Frames
Phenotype
RNA, Messenger
Rats

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