Article
Increased cyclin A and decreased cyclin D levels in adenovirus 5 E1A-transformed rodent cell lines.
Oncogene - 1 Jul 1993
Buchou T, Kranenburg O, van Dam H, Roelen D, Zantema A, Hall F L, van der Eb A
Abstract excerpt
Adenovirus-(Ad)- E1A proteins carry two conserved domains (CR1 and CR2) required for transformation of primary rodent cells and essential for association with cellular proteins, including p105RB, p58cyclin A and p33cdk2. We show that in normal rat kidney 49F (NRK) cell lines expressing various mu...
Topics
- Adenovirus E1A Proteins
- Amino Acid Sequence
- Animals
- Cell Line, Transformed
- Cell Transformation, Neoplastic
- Cyclins
- Molecular Sequence Data
- Mutation
- Rats
- Structure-Activity Relationship