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Article

trans-dominant interference of type 5 adenovirus E1a mutants in cell transformation.

Journal of virology - 1 Apr 1994

Tang Q, Ginsberg H S

Abstract excerpt

Two type 5 adenovirus (Ad5) early region 1a (E1a) mutants, H5in104 and H5dl105, were impaired in viral replication and cell transformation. In addition, these mutants trans dominantly inhibited the frequency with which H5sub309, a phenotypically wild-type mutant, and H5dl520, a high-frequency transformation mutant, transformed CREF cells. Inhibition of transformation varied in proportion to the input ratio of...

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Identifiers

PMID: 8138997
DOI: 10.1128/JVI.68.4.2127-2134.1994
PMCID: PMC236687

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