trans-dominant interference of type 5 adenovirus E1a mutants in cell transformation.

doi:10.1128/JVI.68.4.2127-2134.1994

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Article

trans-dominant interference of type 5 adenovirus E1a mutants in cell transformation.

Journal of virology - 1 Apr 1994

Tang Q, Ginsberg H S

Abstract excerpt

Two type 5 adenovirus (Ad5) early region 1a (E1a) mutants, H5in104 and H5dl105, were impaired in viral replication and cell transformation. In addition, these mutants trans dominantly inhibited the frequency with which H5sub309, a phenotypically wild-type mutant, and H5dl520, a high-frequency tra...

Topics

Adenoviridae
Adenovirus E1A Proteins
Adenovirus E1B Proteins
Animals
Base Sequence
Cell Line
Cell Transformation, Viral
DNA, Viral
Genetic Complementation Test
Humans
Molecular Sequence Data
Mutation
Rats
Sequence Analysis, DNA
Viral Interference
Virus Replication

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