Repression of cyclin D1 expression does not contribute to initiation or maintenance of cell transformation by adenovirus type 5 E1.

doi:10.1128/JVI.70.11.7804-7810.1996

Back to search

Article

Repression of cyclin D1 expression does not contribute to initiation or maintenance of cell transformation by adenovirus type 5 E1.

Journal of virology - 1 Nov 1996

Kranenburg O, Keblusek P, Van der Eb A J, Zantema A

Abstract excerpt

Expression of the gene encoding the cell cycle regulator cyclin D1 is strongly repressed in adenovirus type 5 E1 (Ad5E1)-transformed cells. Since cyclin D1 is a regulator of cell proliferation, modulation of its abundance may affect cell cycle control. Therefore, we studied the importance of cycl...

Topics

Adenovirus E1 Proteins
Animals
Cell Division
Cell Line
Cell Line, Transformed
Chlorocebus aethiops
Clone Cells
Cyclin D1
Cyclins
Gene Expression
Humans
Oncogene Proteins
Phenotype
Transformation, Genetic

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.