High incidence of mutations of the p53 gene detected in ovarian tumours by the use of chemical mismatch cleavage.

doi:10.1016/0304-3835(93)90223-v

Back to search

Article

High incidence of mutations of the p53 gene detected in ovarian tumours by the use of chemical mismatch cleavage.

Cancer letters - 15 Jan 1993

Sheridan E, Hancock B W, Goyns M H

Abstract excerpt

We have investigated a series of ovarian tumours for evidence of mutations in the p53 tumour suppressor gene. In this study we have made use of the chemical mismatch cleavage technique which, from analyses of other genes, has been shown to consistently identify all point mutations present within...

Topics

Base Sequence
DNA, Neoplasm
Female
Genes, p53
Humans
Hydroxylamine
Hydroxylamines
Molecular Sequence Data
Mutation
Osmium Tetroxide
Ovarian Neoplasms
Point Mutation
Polymerase Chain Reaction

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.