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Article

High incidence of mutations of the p53 gene detected in ovarian tumours by the use of chemical mismatch cleavage.

Cancer letters - 15 Jan 1993

Sheridan E, Hancock B W, Goyns M H

Abstract excerpt

We have investigated a series of ovarian tumours for evidence of mutations in the p53 tumour suppressor gene. In this study we have made use of the chemical mismatch cleavage technique which, from analyses of other genes, has been shown to consistently identify all point mutations present within a region of DNA. This approach revealed mutations of p53 in 11/20 tumours studied, mainly in exons 5 or 7. After...

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Identifiers

PMID: 8422653
DOI: 10.1016/0304-3835(93)90223-v

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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