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Mutations spanning P53 exons 5-9 detected by non-isotopic RNAse cleavage assay and protein expression in human colon cancer.

Cancer genetics and cytogenetics - 1 Aug 2001

Tommasi S, Abatangelo M, Lacalamita R, Montemurro S, Marzullo F, Paradiso A

Abstract excerpt

The non-isotopic assay (NIRCA), based on the observation that RNAse is able to specifically cleave a single mismatch in RNA/RNA duplexes, has been recently proposed to detect p53 mutations. To verify the use of this method as a valid screening for P53 mutations in a routinely collected cancer ser...

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PMID: 11520564
DOI: 10.1016/s0165-4608(01)00422-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-11520564-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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