Article
High prevalence of codon 213Arg-->Stop mutations of the TP53 gene in human ovarian cancer in the southwestern part of The Netherlands.
International journal of cancer - 4 May 1998
Schuyer M, Henzen-Logmans S C, van der Burg M E, Fieret E J, Klijn J G, Foekens J A, Berns E M
Abstract excerpt
As in many human malignancies, TP53 mutations are the most common genetic alterations in malignant human ovarian tumours. An approach often used in the determination of TP53 status is immunohistochemical staining of the protein. Non-missense mutations, especially those of the null type, causing premature termination codons and resulting in truncated proteins, may often not be detectable by immunohistochemistry....
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