Identification of early p53 mutations in clam ileocystoplasties using restriction site mutation assay.

doi:10.1016/j.urology.2007.06.1121

Article

Identification of early p53 mutations in clam ileocystoplasties using restriction site mutation assay.

Urology - 1 Nov 2007

Ivil Kenneth D, Jenkins Spencer A, Doak Shareen H, Hawizy Azad M, Kynaston Howard G, Parry Elizabeth M, Jenkins Gareth J S, Parry James M, Stephenson Timothy P

Abstract excerpt

OBJECTIVES: Because a risk of cancer arising in enterocystoplasties exists, it is necessary to identify which patients are most at risk of tumor formation. The aim of this study was to determine whether rare mutated p53 sequences were more common at the enterovesical anastomosis than in the bladder remnant in patients with a clam ileocystoplasty using the restriction site mutation (RSM) assay. METHODS: DNA was...

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Identification of early p53 mutations in clam ileocystoplasties using restriction site mutation assay.

Abstract excerpt

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