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Article

Dominant lethal mutations near the 5' substrate binding site affect RNA polymerase propagation.

The Journal of biological chemistry - 25 Jan 1993

Sagitov V, Nikiforov V, Goldfarb A

Abstract excerpt

The segment Asp1064-Lys1073 in the beta subunit of Escherichia coli RNA polymerase is evolutionarily conserved and is located near the "5' face" of the nucleotide binding pocket as was shown by affinity labeling with priming substrates (Grachev, M. A., Lukhtamov, E. A., Mustaev, A. A., Zaychikov, E. F., Abdukayumov, M. N., Rabinov, I. V., Richter, V. I., Skoblov, Y. S., and Chistyakov, P. G. (1989) Eur. J....

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PMID: 8420987

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