Article
Characterization of a novel RNA polymerase mutant that alters DksA activity.
Journal of bacteriology - 1 Sept 2013
Satory Dominik, Halliday Jennifer A, Sivaramakrishnan Priya, Lua Rhonald C, Herman Christophe
Abstract excerpt
The auxiliary factor DksA is a global transcription regulator and, with the help of ppGpp, controls the nutritional stress response in Escherichia coli. Although the consequences of its modulation of RNA polymerase (RNAP) are becoming better explained, it is still not fully understood how the two proteins interact. We employed a series of genetic suppressor selections to find residues in RNAP that alter its...
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