Article
Mutations in and monoclonal antibody binding to evolutionary hypervariable region of Escherichia coli RNA polymerase beta' subunit inhibit transcript cleavage and transcript elongation.
The Journal of biological chemistry - 18 Sept 1998
Zakharova N, Bass I, Arsenieva E, Nikiforov V, Severinov K
Abstract excerpt
A 190 amino acid-long region centered around position 1050 of the 1407-amino acid-long beta' subunit of Escherichia coli RNA polymerase (RNAP) is absent from homologues in eukaryotes, archaea and many bacteria. In chloroplasts, the corresponding region can be more than 900 amino acids long. The r...
Topics
- Amino Acid Sequence
- Antibodies, Monoclonal
- Bacteria
- Binding Sites, Antibody
- Chloroplasts
- Cloning, Molecular
- DNA-Directed RNA Polymerases
- Escherichia coli
- Evolution, Molecular
- Genetic Variation
- Immunoglobulin Variable Region
- Macromolecular Substances
- Molecular Sequence Data
- Mutagenesis