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Article

A universally conserved region of the largest subunit participates in the active site of RNA polymerase III.

The EMBO journal - 1 Aug 1995

Dieci G, Hermann-Le Denmat S, Lukhtanov E, Thuriaux P, Werner M, Sentenac A

Abstract excerpt

The largest subunits of the three eukaryotic nuclear RNA polymerase present extensive sequence homology with the beta' subunit of the bacterial enzymes over five major co-linear regions. Region d is the most highly conserved and contains a motif, (Y/F)NADFDGD(E/Q)M(N/A), which is invariant in all multimeric RNA polymerases. An extensive mutagenesis of that region in yeast RNA polymerase III led to a vast majority...

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Identifiers

PMID: 7641695
DOI: 10.1002/j.1460-2075.1995.tb00046.x
PMCID: PMC394451

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