Article
A strategically located serine residue is critical for the mutator activity of DNA polymerase IV from Escherichia coli.
Nucleic acids research - 1 May 2013
Sharma Amit, Kottur Jithesh, Narayanan Naveen, Nair Deepak T
Abstract excerpt
The Y-family DNA polymerase IV or PolIV (Escherichia coli) is the founding member of the DinB family and is known to play an important role in stress-induced mutagenesis. We have determined four crystal structures of this enzyme in its pre-catalytic state in complex with substrate DNA presenting the four possible template nucleotides that are paired with the corresponding incoming nucleotide triphosphates. In all...
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