Article
Thrombin-variable region 1 (VR1). Evidence for the dominant contribution of VR1 of serine proteases to their interaction with plasminogen activator inhibitor 1.
The Journal of biological chemistry - 15 Jan 1993
Horrevoets A J, Tans G, Smilde A E, van Zonneveld A J, Pannekoek H
Abstract excerpt
The importance of a specific variable region in different serine proteases for the interaction with plasminogen activator inhibitor 1 (PAI-1) is studied. To that end, we have constructed a thrombin substitution variant, thrombin-VR1, in which the entire variable region 1 (VR1) of the protease dom...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Cell Line
- Chlorocebus aethiops
- Genetic Variation
- Humans
- Kidney
- Kinetics
- Liver
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Oligodeoxyribonucleotides
- Phenylalanine
- Plasminogen Activator Inhibitor 1
- Recombinant Proteins
- Serine Endopeptidases
- Thrombin