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Article

Distal hinge of plasminogen activator inhibitor-1 involves its latency transition and specificities toward serine proteases.

BMC biochemistry - 8 Jul 2003

Wang Qingcai, Shaltiel Shmuel

Abstract excerpt

BACKGROUND: The plasminogen activator inhibitor-1 (PAI-1) spontaneously converts from an inhibitory into a latent form. Specificity of PAI-1 is mainly determined by its reactive site (Arg346-Met347), which interacts with serine residue of tissue-type plasminogen activator (tPA) with concomitant formation of SDS-stable complex. Other sites may also play roles in determining the specificity of PAI-1 toward serine...

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Identifiers

PMID: 12848892
DOI: 10.1186/1471-2091-4-5
PMCID: PMC179894

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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