The M358R variant of α(1)-proteinase inhibitor inhibits coagulation factor VIIa.

doi:10.1016/j.bbrc.2016.01.069

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Article

The M358R variant of α(1)-proteinase inhibitor inhibits coagulation factor VIIa.

Biochemical and biophysical research communications - 12 Feb 2016

Sheffield William P, Bhakta Varsha

Abstract excerpt

The naturally occurring M358R mutation of the plasma serpin α1-proteinase inhibitor (API) changes both its cleavable reactive centre bond to Arg-Ser and the efficacy with which it inhibits different proteases, reducing the rate of inhibition of neutrophil elastase, and enhancing that of thrombin, factor XIa, and kallikrein, by several orders of magnitude. Although another plasma serpin with an Arg-Ser reactive...

Topics

Blood Coagulation
Factor VIIa
Genetic Variation
Humans
Kinetics
Structure-Activity Relationship
Thromboplastin
alpha 1-Antitrypsin

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PMID: 26797521
DOI: 10.1016/j.bbrc.2016.01.069

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