Vitronectin governs the interaction between plasminogen activator inhibitor 1 and tissue-type plasminogen activator.

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Article

Vitronectin governs the interaction between plasminogen activator inhibitor 1 and tissue-type plasminogen activator.

The Journal of biological chemistry - 5 Jun 1991

Keijer J, Ehrlich H J, Linders M, Preissner K T, Pannekoek H

Abstract excerpt

The "serpin" plasminogen activator inhibitor 1 (PAI-1) is the fast acting inhibitor of plasminogen activators (tissue-type (t-PA) and urokinase type-PA) and is an essential regulatory protein of the fibrinolytic system. Its P1-P1' reactive center (R346 M347) acts as a "bait" for tight binding to...

Topics

Base Sequence
Blotting, Western
Electrophoresis, Polyacrylamide Gel
Fibrin
Gene Expression Regulation
Glycoproteins
Heparin
Molecular Sequence Data
Mutation
Plasmids
Plasminogen Inactivators
Tissue Plasminogen Activator
Vitronectin

Source

Open in PubMed

Identifiers

PMID: 1709939

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1709939-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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