Article
Identification of tissue-type plasminogen activator-specific plasminogen activator inhibitor-1 mutants. Evidence that second sites of interaction contribute to target specificity.
The Journal of biological chemistry - 21 Apr 1995
Sherman P M, Lawrence D A, Verhamme I M, Paielli D, Shore J D, Ginsburg D
Abstract excerpt
Plasminogen activator inhibitor-1 (PAI-1) is the primary inhibitor of the plasminogen activators (PAs), tissue-type plasminogen activator (tPA), and urokinase-type plasminogen activator (uPA). A library of PAI-1 mutants containing substitutions at the P1 and P1' positions was screened for functio...
Topics
- Amino Acid Sequence
- Base Sequence
- Heparin
- Molecular Sequence Data
- Mutation
- Plasminogen Activator Inhibitor 1
- Structure-Activity Relationship
- Thrombin
- Tissue Plasminogen Activator