Human thrombin variable region 1, including E39, is involved in interactions with alpha 1-antitrypsin M358R and protein C.

doi:10.1016/0014-5793(95)00457-k

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Article

Human thrombin variable region 1, including E39, is involved in interactions with alpha 1-antitrypsin M358R and protein C.

FEBS letters - 29 May 1995

Gaussem P, Picard V, Chadeuf G, Arnaud E, Aiach M

Abstract excerpt

We used an antithrombin autoantibody (IgG D), the epitope of which encompasses ABE1 and amino acids located within variable region 1, to study thrombin interactions with R358 alpha 1-AT and protein C. IgG D inhibited the thrombin interaction with R358 alpha 1-AT, while hirugen had no effect, indi...

Topics

Amino Acid Sequence
Genetic Variation
Hirudins
Humans
Immunoglobulin G
Kinetics
Molecular Sequence Data
Peptide Fragments
Point Mutation
Protein C
Substrate Specificity
Thrombin
alpha 1-Antitrypsin

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