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Article

Structure-function analysis of the reactive site in the first Kunitz-type domain of human tissue factor pathway inhibitor-2.

The Journal of biological chemistry - 23 Apr 2004

Chand Hitendra S, Schmidt Amy E, Bajaj S Paul, Kisiel Walter

Abstract excerpt

Human tissue factor pathway inhibitor-2 (TFPI-2) is a Kunitz-type proteinase inhibitor that regulates a variety of serine proteinases involved in coagulation and fibrinolysis through their non-productive interaction with a P(1) residue (Arg-24) in its first Kunitz-type domain (KD1). Previous kinetic studies revealed that TFPI-2 was a more effective inhibitor of plasmin than several other serine proteinases, but...

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Source

Identifiers

PMID: 14970225
DOI: 10.1074/jbc.M400802200

Genes

TFPI

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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