Article
Expression of the retinoblastoma susceptibility gene in childhood rhabdomyosarcomas.
Journal of the National Cancer Institute - 20 Jan 1993
De Chiara A, T'Ang A, Triche T J
Abstract excerpt
BACKGROUND: Alveolar and embryonal rhabdomyosarcomas are soft-tissue tumors that occur mainly in childhood. The more aggressive alveolar subtype has been found to possess a characteristic chromosomal abnormality located near the retinoblastoma susceptibility gene (RB1). RB1 is a tumor suppressor gene implicated in the development of retinoblastoma and other, unrelated malignancies, especially osteogenic sarcomas...
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