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Article

Altered Expression of the Retinoblastoma Gene Product in Human Sarcomas

22 Nov 1990

Abstract excerpt

BACKGROUND: The retinoblastoma-susceptibility (Rb) gene is a prototype tumor-suppressor gene originally isolated from patients with heritable retinoblastoma. This gene encodes a nuclear phosphoprotein whose expression is altered in several types of human tumors. METHODS: We studied the expression of the Rb protein in 44 primary and 12 metastatic high-grade human sarcomas by means of immunohistochemical methods...

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PMID: 2233918
DOI: 10.1056/nejm199011223232105

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