Article
RAS signaling dysregulation in human embryonal Rhabdomyosarcoma.
Genes, chromosomes & cancer - 1 Nov 2009
Martinelli Simone, McDowell Heather P, Vigne Silvia Delle, Kokai George, Uccini Stefania, Tartaglia Marco, Dominici Carlo
Abstract excerpt
Rhabdomyosarcoma (RMS) is a common childhood solid tumor, resulting from dysregulation of the skeletal myogenesis program. Two major histological subtypes occur in childhood RMS, embryonal and alveolar. While chromosomal rearrangements account for the majority of alveolar tumors, the genetic defects underlying the pathogenesis of embryonal RMS remain largely undetermined. A few studies performed on small series...
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