Article
Sarcoma and familial retinoblastoma.
Clinical & experimental ophthalmology - 1 Oct 2003
Chen Celia S, Suthers Graeme, Carroll Jacqueline, Rudzki Zbigniew, Muecke James
Abstract excerpt
BACKGROUND: Retinoblastoma is the most common malignant ocular tumour of childhood. It results from mutations in the retinoblastoma gene, RB1, which may be sporadic or heritable. Only 10-25% of patients have a family history of retinoblastoma and can be assumed to have a heritable RB1 mutation. A small proportion of the remaining patients may have a heritable mutation despite the lack of relatives with...
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