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Article

Inactivation of p53 and Retinoblastoma Family Pathways in Canine Osteosarcoma Cell Lines

1 Jan 2000

Abstract excerpt

Canine osteosarcoma (OS) has been used as a model system for the study of cancer biology and treatment despite the lack of information regarding its pathogenesis. Expression of tumor suppressor genes known to participate in malignant transformation were studied in five different OS cell lines. Each of the cell lines exhibited properties of transformed cells, and those that were tested grew in soft agarose and...

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PMID: 10643981
DOI: 10.1354/vp.37-1-54

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Source receipt: pubmed, retrieved 7 Sept 2026.

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