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Sarcomas in hereditary retinoblastoma

4 Oct 2012

Abstract excerpt

Children diagnosed with the hereditary form of retinoblastoma (Rb), a rare eye cancer caused by a germline mutation in the RB1 tumor suppressor gene, have excellent survival, but face an increased risk of bone and soft tissue sarcomas. This predisposition to sarcomas has been attributed to genetic susceptibility due to inactivation of the RB1 gene as well as past radiotherapy for Rb. The majority of bone and soft...

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PMID: 23036192
DOI: 10.1186/2045-3329-2-15

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