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Article

TDP1 and PARP1 deficiency are cytotoxic to rhabdomyosarcoma cells.

Molecular cancer research : MCR - 1 Oct 2013

Fam Hok Khim, Walton Cheryl, Mitra Sheetal A, Chowdhury Miraj, Osborne Nichola, Choi Kunho, Sun Guobin, Wong Patrick C W, O'Sullivan Maureen J, Turashvili Gulisa, Aparicio Samuel, Triche Timothy J, Bond Mason, Pallen Catherine J, Boerkoel Cornelius F

Abstract excerpt

UNLABELLED: Rhabdomyosarcoma is the most common soft tissue sarcoma in children. Metastatic rhabdomyosarcoma in children has a 5-year event-free survival rate of <30%, and a recent clinical trial with irinotecan, a topoisomerase I inhibitor, failed to improve outcome. Therefore, it was surmised that failure of irinotecan may be the result of overexpression of the DNA repair enzyme tyrosyl-DNA phosphodiesterase...

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Share to Myoblasts, Skeletal
Share to Phosphoric Diester Hydrolases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Poly (ADP-Ribose) Polymerase-1

Share to Poly(ADP-ribose) Polymerase Inhibitors

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Source

Identifiers

PMID: 23913164
DOI: 10.1158/1541-7786.MCR-12-0575

Genes

TDP1
PARP1
BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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